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Importantly, this model also suggests that testing for the presence of additional autoantibodies, such as anti-CCAR1 and anti-Sp4, may be helpful in identifying a high-risk, TIF1-positive DM subset in whom malignancy screening would be expected to have a high benefitrisk ratio

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In contrast, PD-linked missense mutations destabilize Syn tetramers, reduce solubility, promote cytoplasmic inclusions, and induce neurotoxicity 67